After it has created and populated the DataTable, the program assigns it to the DataGrid's DataSource property. The grid automatically displays the data and lets the user edit it.

Private Sub Form1_Load(ByVal sender As System.Object, ByVal _
    e As System.EventArgs) Handles MyBase.Load
    Dim dt As New DataTable("People")
    dt.Columns.Add("First Name")
    dt.Columns.Add("Last Name")
    dt.Columns.Add("Occupation")

    dt.Rows.Add(New Object() {"Rod", "Stephens", "Computer " & _
        "Nerd"})
    dt.Rows.Add(New Object() {"Sergio", "Aragones", _
        "Cartoonist"})
    dt.Rows.Add(New Object() {"Eoin", "Colfer", "Author"})
    dt.Rows.Add(New Object() {"Terry", "Pratchett", "?"})

    DataGrid1.DataSource = dt
End Sub

For more information on database programming in VB .NET, see my book Visual Basic .NET Database Programming.